![]() ![]() These patients with either "latent autoimmune diabetes in adulthood" or type 1 diabetes mellitus, may be distinguished from those patients with type 2 diabetes by detection of 1 or more islet autoantibodies, including ZnT8 antibody.(2-5) Patients with gestational diabetes can also be stratified for future diabetes risk by detection of 1 or more islet autoantibodies (including ZnT8 antibody). Isotype: IgG Application Notes: WB: 1:5001:1000 ELISA: 1:10000 Restrictions: For Research Use only Synonyms Zinc transporter 8, ZnT-8, Solute carrier. A value greater than 15.0 Kronus Units/mL is considered positive for Zinc Transporter 8 antibody( ZnT8 ). Because of symptom-onset in adulthood, societal obesity, and initial insulin-independence, some patients with type 1 diabetes are initially diagnosed as having type 2 diabetes. These antibodies are also detectable in relatives of type 1 diabetic patients at risk for developing diabetes, before clinical onset. The BioVendor Zinc Transporter 8 autoantibody (ZnT8 Ab) ELISA kit is intended for use by professional persons only, for the quantitative determination of. One or more of these autoantibodies are detected in 93% to 96% of patients with type 1 diabetes, both adults and children. This is a single-marker test measuring antibodies to zinc transporter 8. These findings have been confirmed in multiple specialty laboratories internationally. Zinc Transporter 8 (ZnT8) Antibody About the Test About the Test. Only 4% to 7% of patients with type 1 diabetes are autoantibody negative, fewer than 10% have only 1 marker, and around 70% have 3 or 4 markers. The ZnT8 autoantibody ELISA is based on the bridging principle that employs the ability of divalent ZnT8 autoantibodies to bind to ZnT8 coated on to the plate well with one arm, and to liquid ZnT8-biotin with the other arm. ![]() These include the insulinoma-associated protein 2 (IA-2), glutamic acid decarboxylase 65 (GAD65), insulin, and, most recently, the zinc transporter ZnT8. Zinc transporter 8 (ZnT8), a protein highly specific to pancreatic insulin-producing beta cells, is vital for the biosynthesis and secretion of insulin. Zinc Transporter 8 (ZnT8) antibodies are principally directed against the C terminal domain of ZnT8. Islet cell autoantibodies have been known to be associated with type 1 diabetes mellitus since the 1970s.(1) Since 1988, several autoantigens against which islet antibodies are directed have been identified. A utoantibodies against zinc transporter 8 are r elated to age, metabolic state and HLA D genotype in children with newly diagnosed type 1 diabetes. ![]()
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